Our Science

A report advocating for person-centred, behaviourally informed approaches to improve outcomes for people living with multiple long-term conditions: Horne, R. Decisions about medicines: scientific evidence in context. Academy of Medical Science. 2017.
Available from: https://acmedsci.ac.uk/file-download/26991434

Necessity-Concerns framework (NCF) applied to understand prescribing behaviour: Pandolfo AM, Horne R, Jani Y, Reader TW, Bidad N, Brealey D, Enne VI, Livermore DM, Gant V, Brett SJ; INHALE WP2 Study Group. Understanding decisions about antibiotic prescribing in ICU: an application of the Necessity Concerns Framework. BMJ Qual Saf. 2022 Mar;31(3):199-210. doi: 10.1136/bmjqs-2020-012479. Epub 2021 Jun 7. PMID: 34099497; PMCID: PMC8899486.
Available from https://pmc.ncbi.nlm.nih.gov/articles/PMC8899486/

Summary paper of adherence from the UCL team: Stewart SF, Moon Z, Horne R. Medication nonadherence: health impact, prevalence, correlates and interventions. Psychol Health. 2023 Jun;38(6):726-765. doi: 10.1080/08870446.2022.2144923. Epub 2022 Nov 29. PMID: 36448201.
Available from https://www.tandfonline.com/doi/10.1080/08870446.2022.2144923?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed#abstract

Demonstrates the impact of a NCF based intervention on objective outcomes: Odeh M, Scullin C, Fleming G, Scott MG, Horne R, McElnay JC. Ensuring continuity of patient care across the healthcare interface: Telephone follow-up post-hospitalization. Br J Clin Pharmacol. 2019 Mar;85(3):616-625. Epub 2019 Jan 24. PMID: 30675742; PMCID: PMC6379220.
Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3846635/

Case study: Applying the Perceptions and Practicalities Approach (PaPA™) to identify behavioural barriers and tailor adherence support after stroke.
Odeh M, Scullin C, Fleming G, Scott MG, Horne R, McElnay JC. Ensuring continuity of patient care across the healthcare interface: Telephone follow-up post-hospitalization. Br J Clin Pharmacol. 2019 Mar;85(3):616-625. doi: 10.1111/bcp.13839. Epub 2019 Jan 24. PMID: 30675742; PMCID: PMC6379220. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6379220/

A landmark meta-analysis confirming that patients’ beliefs about treatment necessity and concerns about medicines are fundamental drivers of medication adherence: Horne R, Chapman SC, Parham R, Freemantle N, Forbes A, Cooper V. Understanding patients’ adherence-related beliefs about medicines prescribed for long-term conditions: a meta-analytic review of the Necessity-Concerns Framework. PLoS One. 2013 Dec 2;8(12):e80633. doi: 10.1371/journal.pone.0080633. PMID: 24312488; PMCID: PMC3846635.
Available from https://pmc.ncbi.nlm.nih.gov/articles/PMC3846635/

Introduces the Perceptions and Practicalities Approach (PaPA™), a pragmatic behavioural framework for tailoring adherence interventions to patients’ beliefs and practical barriers.: Horne, R., Cooper, V., Wileman, V., & Chan, A. (2019). Supporting adherence to medicines for long-term conditions: A perceptions and practicalities approach based on an extended common-sense model. European Psychologist, 24(1), 82–96.
Available from https://doi.org/10.1027/1016-9040/a000353 or https://econtent.hogrefe.com/doi/10.1027/1016-9040/a000353

Case study: A tailored digital intervention using behavioural science to address adherence-related beliefs and practical barriers in inflammatory bowel disease.
Chapman S, Sibelli A, St-Clair Jones A, Forbes A, Chater A, Horne R. Personalised Adherence Support for Maintenance Treatment of Inflammatory Bowel Disease: A Tailored Digital Intervention to Change Adherence-related Beliefs and Barriers. J Crohns Colitis. 2020 Oct 5;14(10):1394-1404. doi: 10.1093/ecco-jcc/jjz034. PMID: 32379303.
Available from https://pubmed.ncbi.nlm.nih.gov/32379303/

MARS demonstrated the best evidence of reliability and validity and ease of administration in a sample of people with RA: Salt E, Hall L, Peden AR, Home R. Psychometric properties of three medication adherence scales in patients with rheumatoid arthritis. J Nurs Meas. 2012;20(1):59-72. doi: 10.1891/1061-3749.20.1.59. PMID: 22679710.
Available from https://connect.springerpub.com/content/sgrjnm/20/1/59

Conference poster reporting TARA results: Horne R, et al (2024). Validation of the Treatment Activation & Adherence Risk Assessment (TARA). 28th ESPACOMP conference, Naples, 2024​.
Link to conference abstract on page 51: https://www.espacomp.eu/wp-content/uploads/2019/06/Posters_ESPACOMP2024__.pdf

MARS-5 validation paper: Chan AHY, Horne R, Hankins M, Chisari C. The Medication Adherence Report Scale: A measurement tool for eliciting patients’ reports of nonadherence. Br J Clin Pharmacol. 2020 Jul;86(7):1281-1288. doi: 10.1111/bcp.14193. Epub 2020 May 18. PMID: 31823381; PMCID: PMC7319010.
Available from https://pmc.ncbi.nlm.nih.gov/articles/PMC7319010/

Studies conducted in the UK NHS that have demonstrated interventions based on the Perceptions and Practicalities Approach (PaPA™) improve adherence and are cost-effective:

Clifford S, Barber N, Elliott R, Hartley E, Horne R. Patient-centred advice is effective in improving adherence to medicines. Pharm World Sci. 2006 Jun;28(3):165-70. doi: 10.1007/s11096-006-9026-6. Epub 2006 Sep 27. PMID: 17004019.
Available from https://link.springer.com/article/10.1007/s11096-006-9026-6

Elliott RA, Barber N, Clifford S, Horne R, Hartley E. The cost effectiveness of a telephone-based pharmacy advisory service to improve adherence to newly prescribed medicines. Pharm World Sci. 2008 Jan;30(1):17-23. doi: 10.1007/s11096-007-9134-y. Epub 2007 Jun 8. PMID: 17557211.
Available from https://link.springer.com/article/10.1007/s11096-007-9134-y

Odeh M, Scullin C, Fleming G, Scott MG, Horne R, McElnay JC. Ensuring continuity of patient care across the healthcare interface: Telephone follow-up post-hospitalization. Br J Clin Pharmacol. 2019 Mar;85(3):616-625. doi: 10.1111/bcp.13839. Epub 2019 Jan 24. PMID: 30675742; PMCID: PMC6379220. Available from https://pmc.ncbi.nlm.nih.gov/articles/PMC6379220/